Why Whole Tumor Vaccine and Regional Chemotherapy can be synergetic?
Not only does Regional Chemotherapy (RCT) allow to limit the side effects, which are associated with systemic chemotherapy, but also it induces a local killing effect on the targeted tumor. It releases all the tumor antigens into the blood system prompting the immune system to activate and act against the cancer tissue.
However, such immune response only lasts for a limited time (usually a few days). The combination of RCT and personalized tumor vaccination can prompt patient’s immune system to fight the cancer longer term. It can also be potentially effective in-parallel with other cancer treatments and regimens. Therefore, it can be beneficial as a part of multimodal cancer treatment approach.